• DocumentCode
    1995238
  • Title

    Ultrasound mediated gene silencing with short-hairpin RNA

  • Author

    Chien Ting Chin ; Hall, C.S. ; Ghanem, Ahmed ; Tiemann, K.

  • Author_Institution
    Ultrasound Imaging & Therapy, Philips Res. North America, Briarcliff Manor, NY, USA
  • fYear
    2009
  • fDate
    20-23 Sept. 2009
  • Firstpage
    1784
  • Lastpage
    1787
  • Abstract
    Ultrasound-mediated delivery (USMD) of drugs and genes, especially with the enhancement of microbubble or nanoparticle agents, has been demonstrated in various settings for some years. Translation to pre-clinical disease models faces many challenges. This paper reports on the development and characteristics of a device for preclinical translational research in USMD. Feasibility of short-haripin RNA (shRNA) delivery in vivo using this device was demonstrated.
  • Keywords
    biomedical ultrasonics; diseases; drugs; gene therapy; macromolecules; molecular biophysics; organic compounds; physiological models; USMD; drugs; gene silencing; genes; microbubble; nanoparticle agents; preclinical disease models; shRNA; short-hairpin RNA; ultrasound-mediated delivery; Animals; DNA; Drugs; Focusing; In vivo; Mice; RNA; Sequences; Ultrasonic imaging; Ultrasonic transducers; RNAi; shRNA; ultrasound mediated gene delivery;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Ultrasonics Symposium (IUS), 2009 IEEE International
  • Conference_Location
    Rome
  • ISSN
    1948-5719
  • Print_ISBN
    978-1-4244-4389-5
  • Electronic_ISBN
    1948-5719
  • Type

    conf

  • DOI
    10.1109/ULTSYM.2009.5441591
  • Filename
    5441591
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=1995238