Title :
Control and reversal of tumor growth by ultrasound activated microbubbles
Author :
Chin, Chien Ting ; Raju, Balasundar I. ; Shevchenko, Talent ; Klibanov, Alexander L.
Author_Institution :
Ultrasound Imaging & Therapy, Philips Res. North America, Briarcliff Manor, NY, USA
Abstract :
It has been known that tumor insonation after intravenous microbubble injection may lead to transient reduction of tumor blood flow. Subsequent experiments showed that repeated induction of tumor blood flow disruption may retard tumor growth. This paper reports an initial investigation of the underlying blood flow disruption phenomena and the first systematic investigation of the control of tumor growth by the combination of moderately intense ultrasound and microbubbles.
Keywords :
biomedical ultrasonics; haemodynamics; radiation therapy; tumours; blood flow disruption; intravenous microbubble injection; microbubbles; tumor blood flow; tumor growth; tumor insonation; Blood flow; Cardiology; Control systems; Lipidomics; Medical treatment; Mice; Neoplasms; North America; Protocols; Ultrasonic imaging; microbubbles; perfusion; therapy; tumor;
Conference_Titel :
Ultrasonics Symposium (IUS), 2009 IEEE International
Conference_Location :
Rome
Print_ISBN :
978-1-4244-4389-5
Electronic_ISBN :
1948-5719
DOI :
10.1109/ULTSYM.2009.5441604
