DocumentCode :
1997068
Title :
Contactless fluorescence imaging with a CMOS image sensor
Author :
Andreou, Andreas G. ; Zhang, Zhaonian ; Özgün, Recep ; Choi, Edward T. ; Kalayjian, Zaven K. ; Marwick, Miriam A. ; Christen, Jennifer Blain ; Tung, Leslie
Author_Institution :
Electr. & Comput. Eng., Johns Hopkins Univ., Baltimore, MD, USA
fYear :
2011
fDate :
15-18 May 2011
Firstpage :
2341
Lastpage :
2344
Abstract :
In this work, we utilize a CMOS active pixel sensor in a fluorescence imaging setup. The ability to sense small light intensity changes on top of a large baseline with spatial resolution at the subcellular scale is required in fluorescence imaging. The CMOS imager presented in [1] is perfect for this application with the ability to resolve fine features coupled with high dynamic range. By using a custom imager with a relay lens we are able to realize a dramatic decrease in device size, cost and complexity of the whole system.
Keywords :
CMOS image sensors; biomedical optical imaging; cellular biophysics; fluorescence; CMOS active pixel sensor; CMOS image sensor; contactless fluorescence imaging; dynamic range; light intensity change; spatial resolution; CMOS integrated circuits; Lenses; Optical imaging; Optical sensors; Pixel; Relays;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Circuits and Systems (ISCAS), 2011 IEEE International Symposium on
Conference_Location :
Rio de Janeiro
ISSN :
0271-4302
Print_ISBN :
978-1-4244-9473-6
Electronic_ISBN :
0271-4302
Type :
conf
DOI :
10.1109/ISCAS.2011.5938072
Filename :
5938072
Link To Document :
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