Model-based parameter estimation in the frequency domain for Quantitative Ultrasound measurement of bone

From Quantitative Ultrasound (QUS) measurements of excised bone samples or intact bones, the multipath transmission of sound waves is a known phenomenon. It has been shown that in the case of superimposed signal components the calculation of the standard QUS parameters Speed-of-Sound (SOS) and Broadband Ultrasound Attenuation (BUA) becomes problematic. Recently, we adapted a model-based parameter estimation in the time domain to allow for evaluating single signal components. Now, we have transferred the parameter estimation into the frequency domain to make its application more flexible. Through applying the model-based signal separation, the uncertainty in computing SOS and BUA is substantially reduced.