Fuzzy C-means for inferring functional coupling of proteins from their phylogenetic profiles

This paper explores the use of the fuzzy C-means clustering algorithm for inferring functional relationships among proteins from their phylogenetic profiles. We conducted a series of experiments using phylogenetic profiles provided by the Cluster of Orthologous Groups of Proteins (COG) database. Experimental results demonstrate that the increasing expressiveness of fuzzy C-means enables the discovery of functional relationships on E.coli operons which traditional methods fail to detect