Nanoliter scale droplet extraction in combination of deformable wall and super hydrophobic pattern in channel

The present paper proposes a nanoliter-scale droplet extraction device using a simple mechanism driven by a deformable wall in combination with a super hydrophobic pattern in a channel. It used to be difficult to form a droplet by a single diaphragm deformation because surface tension inhibits splitting of a liquid in ¿m-scale droplets. The proposed device addresses this problem and express a droplet in combination of a pressure driven diaphragm and a locally hydrophobic region in a channel. The proposed device made of Polydimethylsiloxane (PDMS) and glass could successfully generate a droplet and adjust the droplets the volume of which could be varied from 0.47 nl to 1.10 nl by changing the driving frequency of the diaphragm.