Molecular imaging of tissue with high-contrast multispectral photosensitizing polarimetric imaging techniques

Author

Giakos, George C. ; Adya, Vantana ; Valluru, Keerthi ; Farajipour, Parisa ; Marotta, Stefanie ; Paxitzis, Jim T. ; Becker, Michaeline ; Bathini, Praneeth ; Ambadipudi, K. ; Mandadi, S. MB

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Akron, Akron, OH

fYear

2009

fDate

11-12 May 2009

Firstpage

63

Lastpage

66

Abstract

Backscattered laser beam contributions from biological fluids doped with optically active molecules were measured utilizing single-detection autobalanced polarimetric detection principles. The outcome of this study indicates that both the Detective Quantum Efficiency (DQE) and the Degree of Linear polarization (DOLP) of backscattered optical signals increase with increasing the concentrations of molecular optically active dopants. This translates to enhanced signal-to-noise ratio and contrast.

Keywords

backscatter; biological tissues; biomedical optical imaging; laser applications in medicine; polarimetry; biological fluids; biological tissue; degree of linear polarization; detective quantum efficiency; high contrast multispectral imaging; laser beam backscattering; molecular imaging; optically active molecules; photosensitizing polarimetric imaging; Biological tissues; Biomedical optical imaging; In vivo; Molecular imaging; Optical imaging; Optical noise; Optical refraction; Optical scattering; Optical sensors; Probes; DOLP; DQE; Optically active biological fluids; enhanced backscattering photon detection; high-contrast; polarimetric detection;

fLanguage

English

Publisher

ieee

Conference_Titel

Imaging Systems and Techniques, 2009. IST '09. IEEE International Workshop on

Conference_Location

Shenzhen

Print_ISBN

978-1-4244-3482-4

Electronic_ISBN

978-1-4244-3483-1

Type

conf

DOI

10.1109/IST.2009.5071603

Filename

5071603