Smart drug delivery using electrospun hollow nanofibers

Author

Yang, Haifeng ; Dong, Liang

Author_Institution

Iowa State Univ., Ames, IA, USA

fYear

2010

fDate

24-28 Jan. 2010

Firstpage

308

Lastpage

311

Abstract

This paper report on a novel nano-electro-mechanical systems (NEMS) technology - nanoscale coaxial soft smart system (nCS³) that enables radial displacements of a multi-layered coaxial hollow fiber (CHF) and controlled modulations of a nanofluidic flow patterns inside the CHF responding to changes in local environments. The nCS³ has a unique nanostructure that consists of a liquid core and multiple layers of polymer and stimuli-responsive hydrogel. Smart and controlled release of drug molecules is realized using the nCS³.

Keywords

drug delivery systems; hydrogels; nanobiotechnology; nanofibres; nanofluidics; polymers; NEMS technology; controlled modulations; drug molecules; multilayered coaxial electrospun hollow nanofiber; nanoelectromechanical systems technology; nanofluidic flow patterns; nanoscale coaxial soft smart system; polymer multiple layers; radial displacements; smart drug delivery; stimuli-responsive hydrogel; Biological control systems; Chemical technology; Coaxial components; Control systems; Displacement control; Drug delivery; Mesoporous materials; Nanobioscience; Pharmaceutical technology; Polymers;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems (MEMS), 2010 IEEE 23rd International Conference on

Conference_Location

Wanchai, Hong Kong

ISSN

1084-6999

Print_ISBN

978-1-4244-5761-8

Electronic_ISBN

1084-6999

Type

conf

DOI

10.1109/MEMSYS.2010.5442505

Filename

5442505