Title :
Improved Drug Delivery: Spray Freeze Dried Nano-Liposomal Inhaled Aerosols
Author :
Zhaolin Wang ; Loebenberg, R. ; Sweeney, L. ; Wong, J.P. ; Finlay, W.H.
Author_Institution :
University of Alberta
Abstract :
A novel powder formulation for inhaled aerosol drug delivery of nano-liposomes has been prepared using spray-freeze drying. After saline reconstitution 91% of the liposome particles (mean volume size) were found to be smaller than 600 nm. Upon aerosol dispersion, a fine particle fraction (FPF) of more than 80% was achieved for this formulation with a model drug (ciprofloxacin) using a new passive inhaler (patent pending) at an inhalation flow rate of 60 l/min.
Keywords :
Aerosols; Biomedical imaging; Bovine; Drug delivery; Encapsulation; Lungs; Mice; Powders; Research and development; Spraying;
Conference_Titel :
MEMS, NANO and Smart Systems, 2004. ICMENS 2004. Proceedings. 2004 International Conference on
Conference_Location :
Banff, AB, Canada
Print_ISBN :
0-7695-2189-4
DOI :
10.1109/ICMENS.2004.1508946
