• DocumentCode
    2015010
  • Title

    Improved Drug Delivery: Spray Freeze Dried Nano-Liposomal Inhaled Aerosols

  • Author

    Zhaolin Wang ; Loebenberg, R. ; Sweeney, L. ; Wong, J.P. ; Finlay, W.H.

  • Author_Institution
    University of Alberta
  • fYear
    2004
  • fDate
    25-27 Aug. 2004
  • Firstpage
    196
  • Lastpage
    196
  • Abstract
    A novel powder formulation for inhaled aerosol drug delivery of nano-liposomes has been prepared using spray-freeze drying. After saline reconstitution 91% of the liposome particles (mean volume size) were found to be smaller than 600 nm. Upon aerosol dispersion, a fine particle fraction (FPF) of more than 80% was achieved for this formulation with a model drug (ciprofloxacin) using a new passive inhaler (patent pending) at an inhalation flow rate of 60 l/min.
  • Keywords
    Aerosols; Biomedical imaging; Bovine; Drug delivery; Encapsulation; Lungs; Mice; Powders; Research and development; Spraying;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    MEMS, NANO and Smart Systems, 2004. ICMENS 2004. Proceedings. 2004 International Conference on
  • Conference_Location
    Banff, AB, Canada
  • Print_ISBN
    0-7695-2189-4
  • Type

    conf

  • DOI
    10.1109/ICMENS.2004.1508946
  • Filename
    1508946
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2015010