Nanoparticulate Delivery Systems for Control of Immunity

Biodegradable poly (D, L-lactic-co-glycolic acid) (PLGA) nanoparticles were designed to target antigens and immunomodulatory molecules to dendritic cells. PLGA nanoparticles were shown to be efficiently phagocytosed by murine and human dendritic cells. Nanoparticle delivery of antigens along with immunostimulatory molecules to dendritic cells resulted in induction of antigen-specific immune responses. Alternatively co-delivery of antigens and immunosuppressive molecules to dendritic cells may be used to induce immune tolerance.