"Super Catalytic Antibodies" Cleaving Targeted Molecules of Viruses and Bacterium

It has been a long time-dream for many scientists to obtain a functional protein which can specifically recognize and futhermore enzymatically decompose the targeted antigens such as viral coat proteins or tumor assosiated proteins. At last, we have succeeded to produce such a novel functional protein refered as "Super catalytic antibody". 1. "Super catalytic antibody" destroying envelope gp41 molecule of HIV-1 The monoclonal antibody (41S-2 mAb) was raised against the sequence, which is highly conserved in env protein of many HIV-1 strains. The light chain (41S-2-L) degraded the gp41 derived-peptide (TPRGPDRPEGIEEEGGERDRD) into amino acids with high catalytic activity (kcat/Km=2.8 x 105M-1min-1).