DocumentCode :
2023826
Title :
Governing stem cell fate through inert materials
Author :
Nardo, Paolo Di ; Minieri, Marilena
Author_Institution :
Dept. of Internal Med., Univ. of Rome Tor Vergata, Rome, Italy
fYear :
2011
fDate :
Feb. 28 2011-March 3 2011
Firstpage :
1
Lastpage :
5
Abstract :
A decade of intensive research has not produced consistent results able to allow a safe and cost-effective use of stem cells in the clinical setting. Among the different causes, the vision that the stem cell rejuvenating potential could overwhelm all the other biological cues has demonstrated to be very weak. Instead, it is now clear that stem cell fate is governed by a complex array of multi-parametric signals whose symmetry is fundamental to confine stem sells in a determined state. The modulation of the level of symmetry along the time-scale drives stem cells towards a specific phenotype. Attempts at reproducing in vitro this mechanism has demonstrated that scaffolds made of inert materials but endowed with appropriate topology and physical characteristics can release signals sensed as biologically relevant by stem cells. Exploiting this concept could allow to reproduce in vitro the physiological conditions usually governing cell fate in order to achieve a more complete control of stem cell differentiation for clinical applications.
Keywords :
biomedical materials; cellular biophysics; symmetry; topology; clinical applications; governing stem cell fate; inert materials; multiparametric signals; physiological conditions; stem cell differentiation; stem cell rejuvenating potential; topology; Computer architecture; In vitro; Microprocessors; Polymers; Stem cells; biomaterial; niche differentiation; scaffold; stem cells;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Wireless Communication, Vehicular Technology, Information Theory and Aerospace & Electronic Systems Technology (Wireless VITAE), 2011 2nd International Conference on
Conference_Location :
Chennai
Print_ISBN :
978-1-4577-0786-5
Type :
conf
DOI :
10.1109/WIRELESSVITAE.2011.5940889
Filename :
5940889
Link To Document :
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