Software based bioassay quantization using standard optical disc drives

Author

Pallapa, M. ; Ou, M.L.L. ; Yu, H.-Z. ; Parameswaran, M.

Author_Institution

Sch. of Eng. Sci., Simon Fraser Univ., Burnaby, BC, Canada

fYear

2009

fDate

26-27 Sept. 2009

Firstpage

726

Lastpage

729

Abstract

The compact disc, a ubiquitous optical data storage medium, has been used as a rapid, low-cost, high-capacity screening platform for bioassays. It can be used as a very high-density biomarker detection too. Ten different concentrations (0.32 Â¿g/mL to 1.6 Â¿g/mL) of streptavidin molecules were deposited on two biotin modified compact discs. The discs were scanned in a standard optical drive and the resulting reading errors were analyzed through a CD/DVD data recovery utility software, IsoBuster. The number of erroneous data sectors was found to be proportional to the concentration of streptavidin.

Keywords

disc drives; error detection; optical disc storage; system recovery; CD/DVD data recovery utility software; IsoBuster; biotin modified compact discs; compact disc; screening platform; software based bioassay quantization; standard optical disc drives; standard optical drive; streptavidin molecules; ubiquitous optical data storage medium; very high density biomarker detection; Biomarkers; Biomedical optical imaging; DVD; Drives; Optical refraction; Optical scattering; Optical sensors; Optical variables control; Quantization; Software standards; IsoBuster; biomarker detection; biotinstreptavidin binding; compact disc; error detection;

fLanguage

English

Publisher

ieee

Conference_Titel

Science and Technology for Humanity (TIC-STH), 2009 IEEE Toronto International Conference

Conference_Location

Toronto, ON

Print_ISBN

978-1-4244-3877-8

Electronic_ISBN

978-1-4244-3878-5

Type

conf

DOI

10.1109/TIC-STH.2009.5444403

Filename

5444403