Combined experimental and simulation study of blood clot formation

Author

Xu, Zhiliang ; Lioi, Joshua ; Alber, Mark ; Mu, Jian ; Liu, Xiaomin ; Chen, Danny Z. ; Kamocka, Malgorzata M. ; Rosen, Elliot D.

Author_Institution

Dept. of Math., Univ. of Notre Dame, Notre Dame, IN, USA

fYear

2009

fDate

26-27 Sept. 2009

Firstpage

357

Lastpage

362

Abstract

A multiscale model of blood clot (thrombus) formation is extended by adding a sub-model of the tissue factor (TF) pathway of blood coagulation to provide more biologically relevant description of coagulation process. A combination of experimental approach, image analysis and a multiscale modeling is used for studying role of factor VII and fibrin in limiting growth of a blood clot. The simulations obtained using new extended model, generated a hypothesis that formation of a fiber cap is capable of stopping blood clot growth by blocking release of thrombin, causing activation of platelets, into a blood stream. This was confirmed by comparison with reconstructed three dimensional experimental images of clots formed in mice with normal and limited levels of factor VII.

Keywords

blood; cellular biophysics; coagulation; haemodynamics; blood clot formation; blood coagulation; blood stream; factor VII; fiber cap; fibrin; image analysis; multiscale model; platelets; thrombus formation; tissue factor; Adhesives; Biological system modeling; Biomedical imaging; Blood; Coagulation; Image reconstruction; Injuries; Mice; Proteins; Surface morphology; blood clot; cellular Potts model; image reconstruction and processing; multiscale model; platelet aggregation; stochastic systems; thrombus;

fLanguage

English

Publisher

ieee

Conference_Titel

Science and Technology for Humanity (TIC-STH), 2009 IEEE Toronto International Conference

Conference_Location

Toronto, ON

Print_ISBN

978-1-4244-3877-8

Electronic_ISBN

978-1-4244-3878-5

Type

conf

DOI

10.1109/TIC-STH.2009.5444476

Filename

5444476