Performance bound on depth estimation of bioelectrical source

The unknown depth of bioelectrical sources confined to a horizontal plane in a horizontally layered volume conductor is estimated from noisy measurements of electrical potential on another, parallel plane (e.g. the surface). The Cramer-Rao bound is computed and discussed. Numerical simulation results suggest that the maximum likelihood depth estimate is asymptotically efficient. These results have applications in cardiology, e.g., in determining locations of still-active muscle layers following myocardial infarction.<>