Nanomechanical DNA origami devices as versatile molecular sensors

Author

Kuzuya, Akinori ; Yamazaki, Takahiro ; Yasuda, Kohei ; Sakai, Yusuke ; Yamanaka, Yusei ; Xu, Yan ; Aiba, Yuichiro ; Ohya, Yuichi ; Komiyama, Makoto

Author_Institution

Dept. of Chem. & Mater. Eng., Kansai Univ., Suita, Japan

fYear

2012

fDate

5-8 March 2012

Firstpage

318

Lastpage

321

Abstract

We propose versatile sensing systems for a variety of chemical and biological targets at molecular resolution. We have designed functional nanomechanical DNA origami devices that can be used as “single-molecule beacons”, which consist of two levers approximately 170 nm long connected at a fulcrum. Various single-molecule inorganic/organic targets ranging from metal ions to proteins as well as a unique binding event of a nucleic acid analogue can be visually detected on AFM by a shape transition of the origami devices.

Keywords

DNA; atomic force microscopy; biosensors; metals; molecular biophysics; molecular configurations; nanosensors; proteins; AFM; biological targets; chemical targets; fulcrum; metal ions; molecular resolution; nanomechanical DNA origami devices; nucleic acid analogue; proteins; shape transition; single-molecule beacons; single-molecule inorganic-organic targets; size 170 nm; versatile molecular sensors; Copper; DNA; Ions; Microscopy; Nanoelectromechanical systems; DNA; DNA Origami; Nanomechanical Device; Nanotechnology;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Micro Engineered and Molecular Systems (NEMS), 2012 7th IEEE International Conference on

Conference_Location

Kyoto

Print_ISBN

978-1-4673-1122-9

Type

conf

DOI

10.1109/NEMS.2012.6196783

Filename

6196783