Force Sensing for the Identification of Single-Cell Microorganisms

Author

Lee, A.S. ; Mahapatro, M. ; Requicha, A.A.G. ; Thompson, M.E. ; Zhou, C.

Author_Institution

Lab. for Molecular Robotics, Univ. of Southern California, Los Angeles, CA

fYear

2006

fDate

20-22 Feb. 2006

Firstpage

47

Lastpage

50

Abstract

Identification of cells of a specific type is a fundamental problem both for laboratory analysis and for future nanorobots operating in physiological environments for health care applications. This paper shows that force sensing with atomic force microscopes by using tips functionalized with antibodies is an effective technique for detecting microorganisms that cannot be identified by optical microscopy. Experimental results are presented for the identification of brown tide algae, which are single-cell marine microorganisms with dimensions on the order of 1-2 micrometers, and for several control experiments

Keywords

atomic force microscopy; biomedical measurement; cellular biophysics; force sensors; medical robotics; microorganisms; nanotechnology; antibodies; atomic force microscopes; brown tide algae identification; cantilever sensors; cell recognition; force sensing; health care applications; laboratory analysis; nanorobots operation; physiological environments; single-cell microorganism identification; Atomic force microscopy; DNA; Force measurement; Force sensors; Laboratories; Microorganisms; Nanobioscience; Optical microscopy; Robot sensing systems; Tides;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Robotics and Biomechatronics, 2006. BioRob 2006. The First IEEE/RAS-EMBS International Conference on

Conference_Location

Pisa

Print_ISBN

1-4244-0040-6

Type

conf

DOI

10.1109/BIOROB.2006.1639058

Filename

1639058