Title :
The research of Rat´s epileptic waves based on optogenetics
Author :
Weifeng Liu ; Xuyang Hao ; Kuibin Sun ; Xiaoying Tang ; Hanjun Li
Author_Institution :
Sch. of Life Sci., Beijing Inst. of Technol., Beijing, China
Abstract :
Epilepsy is a kind of brain disease caused by the disorder of large number of brain neuron discharge. In this paper, we use optogenetic animal model of epilepsy to research the changes of brain signals during light stimulation. The results of our experiment show that the light stimulation reduces the number of spike during the seizure effectively, and exerts inhibitory effect on the intensity of seizure. The results demonstrate that optogenetics may provide us a useful tool to control the seizure and possibly other excitability disorders.
Keywords :
bioelectric potentials; cellular biophysics; diseases; electroencephalography; genetics; medical disorders; neurophysiology; brain disease; brain neuron discharge disorder; brain signals; inhibitory effect; light stimulation; optogenetic animal model; rat epileptic waves; seizure intensity; Brain modeling; Electrodes; Electroencephalography; Epilepsy; Mice; Neurons; Electroencephalogram(EEG); Epilepsy; Epileptic waves; Optogenetics; Spike;
Conference_Titel :
Mechatronics and Automation (ICMA), 2015 IEEE International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4799-7097-1
DOI :
10.1109/ICMA.2015.7237524
