Title :
Indentation analysis of tamoxifen-resistant MCF-7 cells by using atomic force microscope
Author :
Hanai, Tatsunori ; Nakakuki, Takashi
Author_Institution :
Major of Mech. Eng., Kogakuin Univ., Tokyo, Japan
Abstract :
In this paper, we measure the elastic modulus of cell surface by indentation test with an atomic force microscope for each of tamoxifen sensitive and resistant breast cancer cell lines. From the comparison of measurements based on statistical test, we demonstrate that tamoxifen resistant cells might be 28% ”softer” than sensitive cells, which evokes the necessity of biomechanistic point of view in cancer research.
Keywords :
atomic force microscopy; biomechanics; cancer; cellular biophysics; drugs; elastic moduli; indentation; statistical testing; atomic force microscope; biomechanistic point; cancer research; cell surface; elastic modulus; indentation test; statistical test; tamoxifen resistant breast cancer cell lines; tamoxifen sensitive breast cancer cell lines; Biomechanics; Breast cancer; Cells (biology); Educational institutions; Force; Immune system; atomic force microscope; breast cancer; drug resistance; elastic modulus; indentation analysis;
Conference_Titel :
SICE Annual Conference (SICE), 2011 Proceedings of
Conference_Location :
Tokyo
Print_ISBN :
978-1-4577-0714-8
