DocumentCode
2040617
Title
Indentation analysis of tamoxifen-resistant MCF-7 cells by using atomic force microscope
Author
Hanai, Tatsunori ; Nakakuki, Takashi
Author_Institution
Major of Mech. Eng., Kogakuin Univ., Tokyo, Japan
fYear
2011
fDate
13-18 Sept. 2011
Firstpage
1168
Lastpage
1171
Abstract
In this paper, we measure the elastic modulus of cell surface by indentation test with an atomic force microscope for each of tamoxifen sensitive and resistant breast cancer cell lines. From the comparison of measurements based on statistical test, we demonstrate that tamoxifen resistant cells might be 28% ”softer” than sensitive cells, which evokes the necessity of biomechanistic point of view in cancer research.
Keywords
atomic force microscopy; biomechanics; cancer; cellular biophysics; drugs; elastic moduli; indentation; statistical testing; atomic force microscope; biomechanistic point; cancer research; cell surface; elastic modulus; indentation test; statistical test; tamoxifen resistant breast cancer cell lines; tamoxifen sensitive breast cancer cell lines; Biomechanics; Breast cancer; Cells (biology); Educational institutions; Force; Immune system; atomic force microscope; breast cancer; drug resistance; elastic modulus; indentation analysis;
fLanguage
English
Publisher
ieee
Conference_Titel
SICE Annual Conference (SICE), 2011 Proceedings of
Conference_Location
Tokyo
ISSN
pending
Print_ISBN
978-1-4577-0714-8
Type
conf
Filename
6060510
Link To Document