Title :
Grid computing simulations of ion channel block effects on the ECG using 3D anatomically-based models
Author :
Bernabeu, Miguel O. ; Corrias, A. ; Pitt-Francis, J. ; Rodriguez, B. ; Bethwaite, B. ; Enticott, C. ; Garic, S. ; Peachey, T. ; Tan, J. ; Abramson, D. ; Gavaghan, D.
Author_Institution :
Comput. Lab., Univ. of Oxford, Oxford, UK
Abstract :
In this study, a computational framework combining state-of-the-art cardiac simulation software and Grid computing is used to investigate the impact of the block of the HERG current on the ECG waveform using state-of-the-art 3D ventricular models of electrophysiology. The technology developed enables (i) automated parameter sweeping using multiscale models (from ion channel to ECG) and (ii) reduced execution time of the simulations performed.
Keywords :
bioelectric phenomena; electrocardiography; grid computing; 3-D anatomically-based models; ECG; HERG; automated parameter sweeping; electrophysiology; grid computing simulations; ion channel block effects; ventricular models; Biological system modeling; Biology computing; Computational geometry; Computational modeling; Computer simulation; Electrocardiography; Grid computing; Heart; Kinetic theory; Laboratories;
Conference_Titel :
Computers in Cardiology, 2009
Conference_Location :
Park City, UT
Print_ISBN :
978-1-4244-7281-9
Electronic_ISBN :
0276-6547
