DocumentCode
2040859
Title
Grid computing simulations of ion channel block effects on the ECG using 3D anatomically-based models
Author
Bernabeu, Miguel O. ; Corrias, A. ; Pitt-Francis, J. ; Rodriguez, B. ; Bethwaite, B. ; Enticott, C. ; Garic, S. ; Peachey, T. ; Tan, J. ; Abramson, D. ; Gavaghan, D.
Author_Institution
Comput. Lab., Univ. of Oxford, Oxford, UK
fYear
2009
fDate
13-16 Sept. 2009
Firstpage
213
Lastpage
216
Abstract
In this study, a computational framework combining state-of-the-art cardiac simulation software and Grid computing is used to investigate the impact of the block of the HERG current on the ECG waveform using state-of-the-art 3D ventricular models of electrophysiology. The technology developed enables (i) automated parameter sweeping using multiscale models (from ion channel to ECG) and (ii) reduced execution time of the simulations performed.
Keywords
bioelectric phenomena; electrocardiography; grid computing; 3-D anatomically-based models; ECG; HERG; automated parameter sweeping; electrophysiology; grid computing simulations; ion channel block effects; ventricular models; Biological system modeling; Biology computing; Computational geometry; Computational modeling; Computer simulation; Electrocardiography; Grid computing; Heart; Kinetic theory; Laboratories;
fLanguage
English
Publisher
ieee
Conference_Titel
Computers in Cardiology, 2009
Conference_Location
Park City, UT
ISSN
0276-6547
Print_ISBN
978-1-4244-7281-9
Electronic_ISBN
0276-6547
Type
conf
Filename
5445433
Link To Document