Design of dual-frequency bioreactor control system

According to tissue engineering and basic principle of bionic, the low-frequency high-amplitude loading on articular cartilage is to simulate human walking or other activities, and the high-frequency low-amplitude loading is to maintain the cartilage framework structure from muscles, ligaments and other tissue. In order to build appropriate mechanical environment for cartilage tissue engineering, this paper design a dual-frequency bioreactor, and the control precision and performance is improved by a method of friction compensation. The control system is full closed loop composed of liner motor and grating scale, based on PC+PMAC opened control platform. Firstly, a dynamic equation of an open servo system is given and the friction characteristics are described based on Stribeck model. Secondly, Considering the parameters of friction model changed with the system, the controller of adaptive sliding friction compensation is designed by backstepping method, and the corresponding adaptive laws and switching functions are given. Besides, this method give analysis of its global asymptotic stability, proved by Lyapunov theorem. Finally, the adaptive sliding friction compensation control strategy is realized by Programmable Multi-Axis Controller (PMAC), and the effectiveness of the method is verified by experiments. Results show that the steady state error of sinusoidal motion is decreased from the ± 22μm to ± 4μm compared with the velocity and acceleration forward feed-compensation. The dual-frequency bioreactor can simulate the mechanical environment of artificial cartilage tissue engineering on micrometer level, furthermore, it laid a foundation for the research of mechanobiology of cartilage.