Segmenting Microarray Image Spots using an Active Contour Approach

Inspired by Paragious and Deriche´s work, which unifies boundary-based and region-based image partition approaches, we integrate the active contour(snake) model and the Fisher criterion to capture, respectively, the boundary and region information of microarray images. We then use the proposed algorithm to automatically segment the spots in the microarray images, and compare our results with those obtained by commercial software.