Run-to-run control of multidimensional crystal size distribution in a batch crystallizer

The control of crystal size and morphology in a potassium dihydrogen phosphate batch crystallization process is investigated. The process is represented by a multidimensional population balance and related differential-algebraic equations. These equations, solved using a high resolution method, are the basis for an optimization and control study. Performances of several operating strategies are compared in terms of delivering crystals in a specific range of size and aspect ratio. Optimization of the operating recipe parameters is further explored. Parameter estimation and recipe optimization are then combined into a run-to-run control scheme and its effectiveness is examined for minimizing the adverse effect of unmeasured disturbances on the final product.