Title :
Model of an approach to targeted drug delivery based on uniform magnetic fields
Author :
Yellen, B.B. ; Forbes, Z.G. ; Barbee, K.A. ; Friedman, G.
Author_Institution :
Dept. of Electr. Eng., Drexel Univ., Philadelphia, PA, USA
fDate :
March 30 2003-April 3 2003
Abstract :
In this paper, a method for inducing highly localised phase transformations at defined locations in the vascular system by applying uniform magnetic fields to an injected superparamagnetic colloidal fluid was investigated. The proposed design involves seeding magnetic particles on to blood vessel walls at designated sites though specific receptor-legend recognition, followed by the use of the anchored particles as magnetic traps for the injected magnetic colloid.
Keywords :
biomagnetism; biomedical materials; blood vessels; drug delivery systems; magnetic field effects; magnetic fluids; magnetic particles; paramagnetic materials; solid-state phase transformations; superparamagnetism; blood vessel walls; drug delivery; injected superparamagnetic colloidal fluid; magnetic particles; magnetic traps; phase transformations; uniform magnetic fields; Biomedical engineering; Drugs; Magnetic analysis; Magnetic fields; Magnetic liquids; Magnetic particles; Predictive models; Saturation magnetization; Stability; Viscosity;
Conference_Titel :
Magnetics Conference, 2003. INTERMAG 2003. IEEE International
Conference_Location :
Boston, MA, USA
Print_ISBN :
0-7803-7647-1
DOI :
10.1109/INTMAG.2003.1230562
