Title :
Ontological Labels for Automated Location of Left Ventricular Remodeling
Author :
Steinert-Threlkeld, Shane ; Ardekani, Siamak ; Mejino, Jose L V ; Detwiler, Landon T. ; Brinkley, James F. ; Halle, Michael ; Kikinis, Ron ; Winslow, Raimond L. ; Miller, Michael I. ; Ratnanather, J. Tilak
Author_Institution :
Center for Imaging Sci., Johns Hopkins Univ., Baltimore, MD, USA
Abstract :
In a previous study, Ardekani et. al. used the Large Deformation Diffeomorphic Metric Mapping (LDDMM) image registration algorithm to analyze the left ventricle of 25 human subjects at both end systole (ES) and end diastole (ED) phases of the cardiac cycle. Of these 25 subjects, 12 had nonischemic cardiomyopathy (NICM) and 13 had ischemic cardiomyopathy (ICM). An average template image at each of ES and ED was generated and then mapped using LDDMM to each patient image. A statistical analysis of the voxel-based Jacobian map, which encodes local tissue volume difference, found one region of statistically significant volume expansion in the NICM group compared to the ICM group. Visual inspection by an expert clinician located this region in the mid anterior subregion of the left ventricle. Using vSPARQL-an extension of SPARQL allowing for recursive and sub-queries the subclass hierarchy surrounding the term Region_of_mγocardium was extracted from the Foundational Model of Anatomy (FMA).
Keywords :
biological tissues; biomedical MRI; electrocardiography; image registration; medical image processing; ontologies (artificial intelligence); statistical analysis; automated location; cardiac cycle; end diastole; end systole; image registration; large deformation diffeomorphic metric mapping; left ventricular remodeling; magnetic resonance image; nonischemic cardiomyopathy; ontological label; patient image; statistical analysis; tissue volume difference; vSPARQL; visual inspection; volume expansion; voxel-based Jacobian map; Biomedical imaging; Educational institutions; Heart; Image segmentation; Myocardium; Ontologies; Cardiac Left Ventricle; Computational Anatomy; Medical Atlases; Ontologies;
Conference_Titel :
Semantic Computing (ICSC), 2011 Fifth IEEE International Conference on
Conference_Location :
Palo Alto, CA
Print_ISBN :
978-1-4577-1648-5
Electronic_ISBN :
978-0-7695-4492-2
DOI :
10.1109/ICSC.2011.99
