Autism: A Systems Biology Disease

Author

Randolph-Gips, Mary

Author_Institution

Syst. & Comput. Eng., Univ. of Houston-Clear Lake, Houston, TX, USA

fYear

2011

fDate

26-29 July 2011

Firstpage

359

Lastpage

366

Abstract

Autism is the fastest growing developmental disorder in the world today. People with autism present with stereotypy and with social and communication impairments. Research has shown that autism has roots in many systems in the body, including the metabolic, mitochondrial, immunological, gastrointestinal and the neurological. These systems interact in complex and highly interdependent ways. Autism poses a rich test bed for systems biology modeling techniques. This paper reviews some of the systems disturbed in autism and suggests several systems biology research areas.

Keywords

cellular biophysics; diseases; molecular biophysics; neurophysiology; autism; communication impairments; developmental disorder; disease; gastrointestinal system; immunological system; metabolic system; mitochondrial system; neurological system; social impairments; stereotypy; systems biology modeling techniques; Autism; Biochemistry; Gastrointestinal tract; Genetics; Immune system; Stress; autism; gastrointestinal; immune; metabolic; modeling; neurological; oxidative stress; systems biology;

fLanguage

English

Publisher

ieee

Conference_Titel

Healthcare Informatics, Imaging and Systems Biology (HISB), 2011 First IEEE International Conference on

Conference_Location

San Jose, CA

Print_ISBN

978-1-4577-0325-6

Electronic_ISBN

978-0-7695-4407-6

Type

conf

DOI

10.1109/HISB.2011.13

Filename

6061466