11.2 A 10.8ps-time-resolution 256×512 image sensor with 2-Tap true-CDS lock-in pixels for fluorescence lifetime imaging

Fluorescence lifetime imaging microscopy (FLIM), which is a nondestructive and minimally invasive manner and can therefore be applied to living cells and tissues, is a great analysis tool in fundamental physics as well as in the life sciences. Charge-coupled devices (CCDs) [1] and single-photon avalanche diodes (SPADs) [2,3] are used for time-resolved lifetime measurement. In particular, SPAD-based time-resolved imagers have a high single-photon sensitivity and good noise robustness. However, they consist of a SPAD array with pixel circuitry, time-to-digital converters (TDCs), digital integrators to amplify signals, and readout circuitry. To implement the high photon-counting rate, a large number of TDCs and digital integrators are required. The spatial resolution of the SPAD-based time-resolved imagers is limited on this account. A recently reported time-resolved CMOS imager [4] using a draining-only modulation (DOM) technique has an attractive feature that a very simple pixel structure and 2-stage charge transfer without transfer gate (TG) can be simultaneously attained. However, it has a small aperture area, a comparatively low transfer speed, and multiple outputs are a challenge.