Title :
Genomic Signal Analysis of MT Mutations Resulting in RMP Resistance
Author :
Cristea, Paul Dan ; Tuduce, Rodica ; Banica, Dorina
Author_Institution :
Univ. Politehnica of Bucharest, Bucharest
Abstract :
The paper applies the GSA methodology to the study of mycobacterium tuberculosis (MT) rpoB gene variability. The rpoB gene encodes the beta subunit of RNA polymerase and can produce rifampin (RMP) resistance, A segment comprising the codons 509-595 of the gene has been analyzed. Mutations occurring at specific sites along the gene strand can be put in direct correspondence to RMP resistance.
Keywords :
diseases; genetic engineering; genetics; medical signal processing; MT mutations; RMP resistance; RNA polymerase; Rifampin resistance; beta subunit; codons 509-595; gene strands; genomic signal analysis; rpoB gene variability; tuberculosis Mycobacterium; Bioinformatics; Drugs; Genetic mutations; Genomics; Immune system; Pathogens; Polymers; RNA; Sequences; Signal analysis; Genomic Signals; Multidrug Pathogen Resistance; Pathogen Variability;
Conference_Titel :
Systems, Signals and Image Processing, 2007 and 6th EURASIP Conference focused on Speech and Image Processing, Multimedia Communications and Services. 14th International Workshop on
Conference_Location :
Maribor
Print_ISBN :
978-961-248-029-5
Electronic_ISBN :
978-961-248-029-5
DOI :
10.1109/IWSSIP.2007.4381154
