Genomic Signal Analysis of MT Mutations Resulting in RMP Resistance

Author

Cristea, Paul Dan ; Tuduce, Rodica ; Banica, Dorina

Author_Institution

Univ. Politehnica of Bucharest, Bucharest

fYear

2007

fDate

27-30 June 2007

Firstpage

65

Lastpage

68

Abstract

The paper applies the GSA methodology to the study of mycobacterium tuberculosis (MT) rpoB gene variability. The rpoB gene encodes the beta subunit of RNA polymerase and can produce rifampin (RMP) resistance, A segment comprising the codons 509-595 of the gene has been analyzed. Mutations occurring at specific sites along the gene strand can be put in direct correspondence to RMP resistance.

Keywords

diseases; genetic engineering; genetics; medical signal processing; MT mutations; RMP resistance; RNA polymerase; Rifampin resistance; beta subunit; codons 509-595; gene strands; genomic signal analysis; rpoB gene variability; tuberculosis Mycobacterium; Bioinformatics; Drugs; Genetic mutations; Genomics; Immune system; Pathogens; Polymers; RNA; Sequences; Signal analysis; Genomic Signals; Multidrug Pathogen Resistance; Pathogen Variability;

fLanguage

English

Publisher

ieee

Conference_Titel

Systems, Signals and Image Processing, 2007 and 6th EURASIP Conference focused on Speech and Image Processing, Multimedia Communications and Services. 14th International Workshop on

Conference_Location

Maribor

Print_ISBN

978-961-248-029-5

Electronic_ISBN

978-961-248-029-5

Type

conf

DOI

10.1109/IWSSIP.2007.4381154

Filename

4381154