Concept of Associated Photodynamic Therapy with Porphyrin – Cis-Platin Drug System and Applications on HeLa Cells

Author

Ion, Rodica Mariana ; Maresca, Luciana ; Migoni, Danilo ; Fanizzi, Francesco P.

Author_Institution

Anal. Dept., ICECHIM, Bucharest

fYear

2008

fDate

June 29 2008-July 5 2008

Firstpage

70

Lastpage

75

Abstract

Photodynamic therapy (PDT) is a clinical approach that uses light-activated drugs for the treatment of different kind of tumor tissues. HeLa tumor cells, as an experimental model for studying the new biomedical concept of associated PDT with 5, 10, 15, 20 -sulphonato-phenyl-porphyrin (TSPP) and an antitumor agent - cisplatin (CisPt), yielded to an enhanced effect on the suppression of tumor cells in vitro. The ultra structure changes of cells caused by the action of the new concept and laser irradiation were analyzed, putting into evidence linear survival curves, by the linear quadratic model.

Keywords

cancer; cellular biophysics; drugs; laser applications in medicine; photodynamic therapy; tumours; HeLa tumor cells; antitumor agent; cis-platin drug system; laser irradiation; light-activated drugs; linear quadratic model; linear survival curves; photodynamic therapy; porphyrin; tumor tissues; Bioinformatics; Biomembranes; Chemicals; Drugs; In vitro; Laser modes; Laser transitions; Medical treatment; Neoplasms; Tumors; CisPt; HeLa; photodynamic therapy; porphyrin;

fLanguage

English

Publisher

ieee

Conference_Titel

Biocomputation, Bioinformatics, and Biomedical Technologies, 2008. BIOTECHNO '08. International Conference on

Conference_Location

Bucharest

Print_ISBN

978-0-7695-3191-5

Electronic_ISBN

978-0-7695-3191-5

Type

conf

DOI

10.1109/BIOTECHNO.2008.35

Filename

4561137