• DocumentCode
    2077967
  • Title

    Control theoretic approach to random branching walk models arising in molecular biology

  • Author

    Swierniak, Andrzej ; Polanski, Andrzej ; Smieja, Jaroslaw ; Kimmel, Marek ; Rzeszowska-Wolny, Joanna

  • Author_Institution
    Dept. of Autom. Control, Silesian Univ. of Technol., Gliwice, Poland
  • Volume
    5
  • fYear
    2002
  • fDate
    2002
  • Firstpage
    3449
  • Abstract
    Techniques commonly used in control theory based on Laplace transforms, spectral analysis, semigroup for state equations, methods of analysis and design of feedback systems enable to characterize the asymptotic behavior of telomeres shortening of which is supposed to be the mechanism of aging and death and cancer cells with increasing number of copies genes responsible for coding proteins causing drug removal or metabolisation. We model these two phenomena by branching random walk processes representing dynamical evolution of particles in them that leads to the systems of infinitely many linear or bilinear state equations. Their transformation into equivalent integro-differential or integral equations allow to design control strategies which are optimal in the sense of some performance indices.
  • Keywords
    Laplace transforms; biocontrol; biocybernetics; control system synthesis; molecular biophysics; Laplace transforms; aging; asymptotic behavior; bilinear state equations; cancer cells; coding proteins; control strategies; control theory; molecular biology; random branching walk models; semigroup; spectral analysis; state equations; telomeres shortening; Aging; Biological control systems; Biological system modeling; Cells (biology); Computational biology; Control theory; Integral equations; Laplace equations; Spectral analysis; State feedback;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    American Control Conference, 2002. Proceedings of the 2002
  • ISSN
    0743-1619
  • Print_ISBN
    0-7803-7298-0
  • Type

    conf

  • DOI
    10.1109/ACC.2002.1024460
  • Filename
    1024460