Computer-aided diagnosis of proliferative diabetic retinopathy

Monitoring the openness of the major temporal arcade (MTA) and how it changes over time could facilitate improved diagnosis and timely treatment of proliferative diabetic retinopathy (PDR). We present methods for user-guided modeling and measurement of the openness of the MTA based on a form of the generalized Hough transform for the detection of parabolas, and to compare it with a method of arcade angle measurement. The methods, implemented via a graphical user interface, were tested with retinal fundus images of 10 normal individuals and 15 patients with PDR. The results using the openness parameters of single- and dual-parabolic models as well as the arcade angle measurements indicate areas under the receiver operating characteristics of A_z= 0.94, 0.87, and 0.84, respectively. The proposed methods should facilitate improved quantitative analysis of the architecture of the MTA, as well as assist in detection, diagnosis, and improved treatment of PDR.