Intradermal needle-free powdered drug injection by a helium-powered device

Author

Liu, Jiangchuan ; Hogan, N.C. ; Hunter, Ian W.

Author_Institution

Dept. of Mech. Eng., Bioinstrumentation Lab., Cambridge, MA, USA

fYear

2012

fDate

Aug. 28 2012-Sept. 1 2012

Firstpage

2068

Lastpage

2071

Abstract

We present a new method for needle-free powdered drug injection via a bench-top gas-powered device. This injector provides an alternative method of vaccine delivery to address the cold chain problem-the cost and risk of transporting temperature sensitive vaccines to developing countries. The device houses interchangeable nozzle inserts to vary orifice geometries and is capable of delivering polymer beads (1-5 μm diameter) into the dermal layer of porcine tissue. Results for injection shape and injection depth versus nozzle orifice diameter demonstrate the device´s controllability.

Keywords

biomedical equipment; drug delivery systems; drugs; nozzles; orifices (mechanical); polymers; powders; skin; bench-top gas-powered device; cold chain problem; dermal layer; developing countries; device controllability; helium-powered device; injection depth; injection shape; injector; interchangeable nozzle; intradermal needle-free powdered drug injection; nozzle orifice diameter; orifice geometries; polymer beads delivery; porcine tissue; size 1 mum to 5 mum; temperature sensitive vaccines; vaccine delivery; Dispersion; Drugs; Immune system; Orifices; Powders; Shape; Vaccines; Animals; Electric Power Supplies; Equipment Design; Equipment Failure Analysis; Helium; Injections, Intradermal; Injections, Jet; Needles; Powders; Swine; Vaccination; Vaccines;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE

Conference_Location

San Diego, CA

ISSN

1557-170X

Print_ISBN

978-1-4244-4119-8

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/EMBC.2012.6346366

Filename

6346366