Title :
The Multi-center Study on Alzheimer´s Disease Using FDG PET
Author :
Baoci, Shan ; Xiuli, Yuan ; Yunchuan, Ma ; Kaida, Jiang ; Qiuyun, Cao ; Jiahe, Tian ; Ruimin, Wang ; Na, Lu
Author_Institution :
Chinese Acad. of Sci., Beijing
Abstract :
The multi-center FDG PET data of normal controls and patients with probable Alzheimer´s disease (AD) were analyzed using SPM (statistical parametric mapping). The results have shown that the hypo-metabolic cerebral areas of patients with probable AD, comparing with health controls, were very consistent in the results of four group data from three PET centers. The significant hypo-metabolic areas located at the posterior cingulate, the joint area of temporal, parietal and occipital cortex, the inferior temporal gyrus and prefrontal cortex. The results of this multi-center study indicated that FDG PET scans might provide a reliable reference marker for AD diagnosis.
Keywords :
brain; diseases; positron emission tomography; AD diagnosis; Alzheimer´s disease; FDG PET; hypometabolic cerebral areas; inferior temporal gyrus; multicenter study; occipital cortex; parietal cortex; prefrontal cortex; reference marker; statistical parametric mapping; temporal cortex; Alzheimer´s disease; Biochemistry; Biomedical imaging; Hospitals; Medical diagnostic imaging; Performance analysis; Positron emission tomography; Scanning probe microscopy; Sugar; Testing; Alzheimer disease; PET; glucose metabolism; multicenter study;
Conference_Titel :
Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-1077-4
Electronic_ISBN :
978-1-4244-1078-1
DOI :
10.1109/ICCME.2007.4381876
