Title :
The Study of Low-frequency Ultrasound to Enhance Transdermal Drug Delivery
Author :
Cui, Jianguo ; Wei, Yunlong ; Wang, Hong
Abstract :
Low-frequency ultrasound(20 kHz lesf les100 kHz) has been extensively researched only in last 10 years. It has been shown to enhance transdermal transport of a variety of drugs. Transdermal drug delivery (TDD) offers several advantages over traditional delivery methods including injection and oral delivery. Low-frequency ultrasound has been shown to increase skin permeability to a variety of low-molecular as well as high-molecular weight drugs. The enhancement is determined by various parameters, including intensity, duty cycle, and application time. This review summarizes applications and mechanisms of low-frequency sonophoresis. Low-frequency ultrasound has been shown to synergistically enhance skin permeability with chemical enhancers, iontophoresis and eleetroporation. Sonophoresis may therefore potentially be applied for non-invasive and painless delivery of drugs in the treatment of some disease.
Keywords :
biomedical ultrasonics; drug delivery systems; permeability; skin; TDD enhancement; electroporation; frequency 20 kHz to 100 kHz; iontophoresis; low frequency sonophoresis; low frequency ultrasound; painless noninvasive drug delivery; skin permeability; transdermal drug delivery; ultrasonic intensity; ultrasound application time; ultrasound duty cycle; Blood; Drug delivery; Epidermis; Humans; In vivo; Insulin; Permeability; Skin; Sugar; Ultrasonic imaging;
Conference_Titel :
Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-1077-4
Electronic_ISBN :
978-1-4244-1078-1
DOI :
10.1109/ICCME.2007.4381938
