Title :
Effects of electroconvulsive therapy stimulus pulsewidth and amplitude computed with an anatomically-realistic head model
Author :
Siwei Bai ; Loo, C. ; Dokos, Socrates
Author_Institution :
Grad. Sch. of Biomed. Eng., Univ. of New South Wales (UNSW), Sydney, NSW, Australia
fDate :
Aug. 28 2012-Sept. 1 2012
Abstract :
The efficacy and cognitive outcomes of electro-convulsive therapy (ECT) on psychiatric disorders have been shown to depend on variations in treatment technique. In order to investigate this, a high resolution finite element human head model was generated from MRI scans and implemented with tissue heterogeneity and an excitable ionic neural formulations in the brain. The model was used to compare the effects of altered ECT stimulus amplitude and pulse width on the spatial extent of directly activated brain regions. The results showed that decreases in both amplitude and pulse width could effectively lead to reductions in the size of activated brain regions.
Keywords :
bioelectric phenomena; biomedical MRI; brain models; finite element analysis; image resolution; medical disorders; medical image processing; patient treatment; MRI scan; anatomically-realistic head model; brain region; cognitive outcome; electroconvulsive therapy stimulus amplitude; electroconvulsive therapy stimulus pulsewidth; excitable ionic neural formulation; high resolution finite element human head model; psychiatric disorder; tissue heterogeneity; Brain modeling; Computational modeling; Conductivity; Electrodes; Head; Humans; Medical treatment; Anisotropy; Computer Simulation; Electroconvulsive Therapy; Head; Humans; Models, Anatomic;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4244-4119-8
Electronic_ISBN :
1557-170X
DOI :
10.1109/EMBC.2012.6346486
