Title :
A Correlation Analysis on Multiplex Three-Dimensional Brain Gene Expression Mapping of Parkinson Disease
Author :
Liu, Qiang ; Li, Haiyun
Author_Institution :
Capital Med. Univ., Beijing
Abstract :
This paper is aimed to predict Parkinson disease (PD) genes from multiplex Three-Dimensional brain gene expression mapping. First, we select the available data from the original datasets and use log ratio as the object that we would analysis. Second, correlation coefficient calculated provides information on the correlation between genes based on gene expression levels. Later, classification and hierarchical cluster analysis can help us to find the relevant genes of Parkinson disease. The 27 genes selected by the statistical method are worthy of further experiments to assess the results of microarray.
Keywords :
biology computing; diseases; genetics; pattern clustering; statistical analysis; Parkinson disease; classification; correlation analysis; correlation coefficient; hierarchical cluster analysis; multiplex 3D brain gene expression mapping; Biomedical engineering; Brain modeling; Gene expression; Genetics; Humans; Mice; Parkinson´s disease; Pathogens; Predictive models; Statistical analysis; PD; classification; correlation coefficient; hierarchical cluster analysis;
Conference_Titel :
Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-1077-4
Electronic_ISBN :
978-1-4244-1078-1
DOI :
10.1109/ICCME.2007.4382015