Title :
Study on effects of two kinds of cactus polysaccharides on the protein contents and the lipid fluidity of erythrocyte membrane in S180 mice
Author :
Chenfeng, Ji ; Yubin, Ji ; Xiang, Zou
Author_Institution :
Harbin Univ. of Commerce, Harbin
Abstract :
To study the effects of two kinds of cactus polysaccharides on band 3 protein content, cross-linking protein content, and the lipid fluidity of erythrocyte membrane in S180 mice. Membrane protein content is analyzed by SDS-PAGE, and lipid fluidity of the membrane is measured by the Skinitzky method. The two kinds of cactus polysaccharide increase the content of band 3 protein, decrease the content of cross-linking protein, and increase lipid fluidity. For medical cactus polysaccharide, the effect of the medium dosage group is significant (P><0.01); but for edible cactus polysaccharide, it is the high dosage group that has a significant effect (P<0.01). By improving the functioning of erythrocyte membrane of tumor-bearing mice, the two kinds of cactus polysaccharides enhance their immunological function, and this may be one of the anti-tumor mechanisms of cactus polysaccharides.
Keywords :
biochemistry; biomembranes; cancer; cellular biophysics; drugs; lipid bilayers; molecular biophysics; proteins; tumours; S180 mice; SDS-PAGE; Skinitzky method; antitumor mechanism; cactus polysaccharides effects; cross-linking protein; dosage; erythrocyte membrane; immunological function; lipid fluidity; protein contents; tumor-bearing mice; Animals; Biomedical imaging; Biomembranes; Buffer storage; Instruments; Lipidomics; Mice; Neoplasms; Pharmaceuticals; Proteins; band 3 protein; cactus; cross-linking protein; lipid fluidity; polysaccharide;
Conference_Titel :
Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-1077-4
Electronic_ISBN :
978-1-4244-1078-1
DOI :
10.1109/ICCME.2007.4382034
