Time-Resolved Fluorescence Detection on Microfluidic Chip for HIV-1 Virus Assay

Author

Sun, Yi ; Wang, Xiansong ; Xie, Fei ; Feng, Juan ; Ma, Xuemei

Author_Institution

Beijing Univ. of Technol., Beijing

fYear

2007

fDate

23-27 May 2007

Firstpage

1761

Lastpage

1765

Abstract

A novel strategy is proposed to greatly reduce the volume and cost of a time-resolved fluorescence detection system. Laser diode is employed as a replacement for ultra-fast DPSS lasers that are expensive and bulky, thus facilitating implementation in microfluidic chip platforms. Besides, corresponding noise-reduction strategy is provided. This method paves way for ultra-sensitive detection of HIV-1 and beyond.

Keywords

bio-optics; bioMEMS; biomolecular effects of radiation; diseases; fluorescence spectroscopy; lab-on-a-chip; laser applications in medicine; microfluidics; microorganisms; patient diagnosis; time resolved spectroscopy; HIV-1 virus assay; Laser diode; human immunodeficiency virus; microfluidic chip platforms; noise reduction; time-resolved fluorescence detection system; ultrasensitive HIV-1 detection; Acquired immune deficiency syndrome; Biomedical engineering; Educational institutions; Fluorescence; Human immunodeficiency virus; Instruments; Microfluidics; Patient monitoring; Sun; Time domain analysis; HIV; fluorescence; microfluidic; time-resolved;

fLanguage

English

Publisher

ieee

Conference_Titel

Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-1077-4

Electronic_ISBN

978-1-4244-1078-1

Type

conf

DOI

10.1109/ICCME.2007.4382050

Filename

4382050