Title :
Study on the influence of Konjac glucomannan on assaying domperidone in orally disintergrating tablets
Author :
Yu, Yuhong ; Pan, Lin ; Ma, Jianlong ; Dai, Rongji ; Deng, Yulin
Author_Institution :
Beijing Inst. of Technol., Beijing
Abstract :
To evaluate the influence of Konjac glucomannan (KGM) on assaying domperidone in orally disintergrating tablets, We established an RP-HPLC method for the determination of domperidone in dompoeridone orally disintergrating tablets. Then KGM was added to the prescription. Good resolution was obtained after the sample was destroyed by acid, alkali and heat. The results suggested that KGM had the potential to be used in drug delivery systems.
Keywords :
chromatography; drugs; organic compounds; Konjac glucomannan; RP-HPLC method; domperidone; drug delivery system; orally disintergrating tablet; reverse phase high-performance liquid chromatography; Blood; Drug delivery; Humans; Immune system; Intestines; Methanol; Pharmaceuticals; Polymers; Sugar industry; Temperature;
Conference_Titel :
Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-1077-4
Electronic_ISBN :
978-1-4244-1078-1
DOI :
10.1109/ICCME.2007.4382062
