Title :
Separation of 2-HPA by Capillary Electrophoresis
Author :
Dai, Rongji ; Yang, Lin ; Liu, Wei ; Deng, Yulin
Author_Institution :
Beijing Inst. of Technol., Beijing
Abstract :
The enantiomers of three chiral compounds of neural interest, N-(2-heptyl)propargylamine (2-HPA), 2-heptylamine (2-HA) and 2-HPPA were separated analytically using capillary electrophoresis (CE) with cyclodextrin chiral selectors. And dansyl chloride was chosen as the reagent for pre-column derivation to give 2-HPA derivatives. The effects of pH, beta-CD concentration, electrolyte concentration and temperature et al. on the chiral separation are investigated in detail. CE is shown to be a simple, efficient, and inexpensive way to separate these three chiral compounds in laboratory.
Keywords :
biochemistry; chirality; chromatography; drugs; electrophoresis; isomerism; organic compounds; separation; 2-HPA; 2-heptylamine; N-(2-heptyl)propargylamine; capillary electrophoresis; chiral compounds; chiral separation; cyclodextrin chiral selectors; dansyl chloride; electrolyte concentration; enantiomers; Biomedical optical imaging; Drugs; Electrokinetics; Gas chromatography; Hydrogen; Laboratories; Neural networks; Optical buffering; Parkinson´s disease; Temperature; 2-HPA; capillary electrophoresis; chiral separation; dansylchloride;
Conference_Titel :
Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-1077-4
Electronic_ISBN :
978-1-4244-1078-1
DOI :
10.1109/ICCME.2007.4382074
