A Novel Micro-spraying System for Preparing Polymer-coated Intravascular Stent

In order to prepare the polymer coating effectively and simply on the stent, which avails producing the drug eluting stent (DES), a novel micro-spraying system was introduced in this paper. Based on the theory of ultrasonic atomization, the spray system was designed and established which was composed of four primary modules. The optimized spray parameters were also determined through orthogonal experiment for preparing coating by the system. The fluorescence stain and image analysis were used to make the morphologies of coating more apparent. Our experimental results reveal that the spray system designed in this paper is suitable for preparing polymer coating, which will facilitate the development of DES.