Title :
A New Non-viral Conjugate as a Promising Carrier System for DNA Delivery
Author :
Wu, Yundong ; Liu, Chengbin ; Zhao, Xiangyun ; Xiang, Jiannan ; Nie, Shuming
Author_Institution :
Hunan Univ., Changsha
Abstract :
A new nonviral conjugate, chitosan-g-PEI-g-PEG-OH polymer, was synthesized using grafting reaction with chitosan, polyethylenimine and polyethylene glycol for constructing amphiphilic grafting copolymers. The conjugates were characterized by IR and 1HNMR, and can self-assembled to form micelle-like nanoparticles in the aqueous media at the PH value of 5. The size of the nanoparticles was in the range of 30-50 nm. The hydrotropic polymer micelles provide an alternative approach for DNA delivery.
Keywords :
DNA; biochemistry; biological NMR; infrared spectra; molecular biophysics; nanobiotechnology; nanoparticles; polymer blends; self-assembly; DNA delivery; amphiphilic grafting copolymers; chitosan-g-PEI-g-PEG-OH polymer; grafting reaction; hydrotropic polymer micelles; micelle-like nanoparticles; nonviral conjugate; polyethylene glycol; polyethylenimine; self-assembly; size 30 nm to 50 nm; Biodegradable materials; Biological materials; Biomedical engineering; Chemistry; DNA; Immune system; Nanoparticles; Nuclear magnetic resonance; Polyethylene; Polymers; Chitosan; Non-viral carrier; Polyethylene glycol; Polyethylenimine;
Conference_Titel :
Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-1077-4
Electronic_ISBN :
978-1-4244-1078-1
DOI :
10.1109/ICCME.2007.4382093
