A New Non-viral Conjugate as a Promising Carrier System for DNA Delivery

Author

Wu, Yundong ; Liu, Chengbin ; Zhao, Xiangyun ; Xiang, Jiannan ; Nie, Shuming

Author_Institution

Hunan Univ., Changsha

fYear

2007

fDate

23-27 May 2007

Firstpage

1974

Lastpage

1977

Abstract

A new nonviral conjugate, chitosan-g-PEI-g-PEG-OH polymer, was synthesized using grafting reaction with chitosan, polyethylenimine and polyethylene glycol for constructing amphiphilic grafting copolymers. The conjugates were characterized by IR and ¹HNMR, and can self-assembled to form micelle-like nanoparticles in the aqueous media at the PH value of 5. The size of the nanoparticles was in the range of 30-50 nm. The hydrotropic polymer micelles provide an alternative approach for DNA delivery.

Keywords

DNA; biochemistry; biological NMR; infrared spectra; molecular biophysics; nanobiotechnology; nanoparticles; polymer blends; self-assembly; DNA delivery; amphiphilic grafting copolymers; chitosan-g-PEI-g-PEG-OH polymer; grafting reaction; hydrotropic polymer micelles; micelle-like nanoparticles; nonviral conjugate; polyethylene glycol; polyethylenimine; self-assembly; size 30 nm to 50 nm; Biodegradable materials; Biological materials; Biomedical engineering; Chemistry; DNA; Immune system; Nanoparticles; Nuclear magnetic resonance; Polyethylene; Polymers; Chitosan; Non-viral carrier; Polyethylene glycol; Polyethylenimine;

fLanguage

English

Publisher

ieee

Conference_Titel

Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-1077-4

Electronic_ISBN

978-1-4244-1078-1

Type

conf

DOI

10.1109/ICCME.2007.4382093

Filename

4382093