Title :
Single Linkage Clustering Fit for Establishing Theoretical MAPK/Erk Signaling Pathway in Human Soft Tissue Sarcoma Samples
Author :
Zhang Jinling ; Lu Yinghua ; Wang Lin ; Zhang Hongxin ; Li Rongrong ; Wang Lin ; Wolfl, Stefan
Author_Institution :
Sch. of Electron. Eng., Beijing Univ. of Posts & Telecommun., Beijing, China
Abstract :
The aim of this research is to use and compare clustering technologies and And the best method for establishing theoretical MAPK/Erk signaling pathway in human soft tissue sarcoma samples. We use and compare centroid linkage, single linkage, complete linkage, average linkage hierarchical clustering to arrange genes to setup signaling pathways according to similarity in pattern of gene. Our results show that only single linkage clustering architecture is consistent with the core unit of the cascade composed of from a RAF1, a MAPKK (MEK1/2) to MAPK (Erk). An activated Erk phosphorylates a variety of transcription factors regulating gene expression, such as Elkl. This study implies that single linkage clustering fit for establishing theoretical MAPK/Erk signaling pathway in human soft tissue sarcoma samples which is consistent with biological experimental MAPK/Erk signaling pathway.
Keywords :
bioinformatics; biological tissues; genetics; molecular biophysics; pattern clustering; activated Erk phosphorylates; centroid linkage; gene expression; human soft tissue sarcoma samples; single linkage; single linkage clustering architecture; theoretical MAPK-Erk signaling pathway; Amino acids; Bioinformatics; Biological tissues; Clustering algorithms; Couplings; Data analysis; Gene expression; Humans; Information analysis; Proteins;
Conference_Titel :
Biomedical Engineering and Informatics, 2009. BMEI '09. 2nd International Conference on
Conference_Location :
Tianjin
Print_ISBN :
978-1-4244-4132-7
Electronic_ISBN :
978-1-4244-4134-1
DOI :
10.1109/BMEI.2009.5301980
