Title :
Interaction of skin tissue with nanosecond pulsed laser-induced stress wave used for gene transfection
Author :
Sato, Shunichi ; Terakawa, Mitsuhiro ; Takano, Shinta ; Tsuda, Hitoshi ; Ashida, Hiroshi ; Okano, Hideyuki ; Obara, Minoru
Author_Institution :
Nat. Defense Med. Coll. Res. Inst., Saitama
Abstract :
In the skin exposed to laser-induced stress wave (LISW), tissue alteration was limited under the optimum conditions for transfection. Efficient gene expression observed in a "LISW first" delivery mode suggests a new mechanism for transfection.
Keywords :
biological effects of laser radiation; biomedical equipment; cellular biophysics; delivery mode; gene expression; gene transfection; nanosecond pulsed laser-induced stress wave; skin tissue; Chemical lasers; DNA; Educational institutions; Gene expression; Laser theory; Optical pulses; Proteins; Skin; Space vector pulse width modulation; Stress;
Conference_Titel :
Lasers and Electro-Optics Society, 2007. LEOS 2007. The 20th Annual Meeting of the IEEE
Conference_Location :
Lake Buena Vista, FL
Print_ISBN :
978-1-4244-0925-9
Electronic_ISBN :
1092-8081
DOI :
10.1109/LEOS.2007.4382323
