Age-dependent pupillary light reflex parameters in children

Author

Daluwatte, C. ; Miles, J.H. ; Christ, S.E. ; Beversdorf, D.Q. ; Lofgreen, A. ; Berliner, N. ; Gang Yao

Author_Institution

Dept. of Biol. Eng., Univ. of Missouri, Columbia, MO, USA

fYear

2012

fDate

Aug. 28 2012-Sept. 1 2012

Firstpage

3776

Lastpage

3779

Abstract

Pupillary light reflex (PLR) refers to the phenomenon where pupil size changes in response to stimulation with a flash of light. It is a simple functional test that can reveal dysfunctions associated with the PLR pathway. Although abnormal PLR responses have been reported in many neurological disorders, few studies investigated neurodevelopmental effects on PLR parameters. We studied the effect of age on PLR in a group of 6 to 17 year old children with typical development. A significant and consistent age effect was found on PLR latency in children younger than 10 years old. Age effects were also observed in resting pupil diameter and constriction amplitude. However such age related trends were not observed in children with neurodevelopment disorders. These results suggest that PLR has the potential to be used as a simple noninvasive tool for monitoring neurodevelopment in children.

Keywords

biomedical optical imaging; eye; medical disorders; medical image processing; neurophysiology; paediatrics; patient monitoring; age 6 yr to 17 yr; age-dependent pupillary light reflex parameters; children; constriction amplitude; light flash stimulation; neurodevelopment disorders; neurodevelopment monitoring; neurodevelopmental effects; neurological disorders; pupil size; resting pupil diameter; Autism; Educational institutions; Market research; Optical filters; Pediatrics; USA Councils; Visualization; Adaptation, Ocular; Adolescent; Aging; Child; Female; Humans; Light; Male; Nervous System; Pupil; Reflex, Pupillary;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE

Conference_Location

San Diego, CA

ISSN

1557-170X

Print_ISBN

978-1-4244-4119-8

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/EMBC.2012.6346789

Filename

6346789