Nanotopography effects on astrocyte attachment to nanoporous gold surfaces

Author

Kurtulus, O. ; Seker, E.

Author_Institution

Dept. of Chem. Eng. & Mater. Sci., Univ. of California, Davis, Davis, CA, USA

fYear

2012

fDate

Aug. 28 2012-Sept. 1 2012

Firstpage

6568

Lastpage

6571

Abstract

Nanoporous gold, synthesized by a self-assembly process, is a new biomaterial with desirable attributes, including tunable nanotopography, drug delivery potential, electrical conductivity, and compatibility with conventional microfabrication techniques. This study reports on the effect of nanotopography in guiding cellular attachment on nanoporous gold surfaces. While the changes in topography do not affect adherent cell density, average cell area displays a non-monotonic dependence on nanotopography.

Keywords

biomedical materials; cellular biophysics; gold; nanomedicine; nanoporous materials; self-assembly; surface topography; Au; astrocyte attachment; biomaterial; cellular attachment guiding; compatibility; drug delivery potential; electrical conductivity; microfabrication; nanoporous gold surface; nanotopography effect; self assembly; tunable nanotopography; Adhesives; Computer architecture; Gold; Microprocessors; Nanotopography; Surface treatment; Animals; Astrocytes; Biocompatible Materials; Cell Adhesion; Cell Culture Techniques; Drug Delivery Systems; Electric Conductivity; Electrodes; Gold; Metal Nanoparticles; Mice; Microscopy, Electron, Scanning; Nanotechnology; Porosity; Temperature;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE

Conference_Location

San Diego, CA

ISSN

1557-170X

Print_ISBN

978-1-4244-4119-8

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/EMBC.2012.6347499

Filename

6347499