Characterization of thin-film microelectrode array and signal conditioning microchip for high spatial resolution Surface Laplacian measurement

Surface Laplacian (SL) electrograms have been found to be superior to unipolar electrograms in detecting local activation by providing local activation time, activation block and wavefront initiation information. Traditional electrode configurations do not provide adequate spatial resolution or signal-to-noise ratios (SNRs) to measure SLs accurately in vivo. The purpose of this work is to develop a customized thin-film microelectrode array (TFMEA) with a custom multichannel signal conditioning microchip (SCM) that significantly improves the SNRs to make high-quality SL measurements feasible. In vitro and in vivo testing and characterization results clearly demonstrate the ability of the TFMEA-SCM system to obtain detailed SL measurements.