Silicon nanowires for high-sensitivity CRP detection

Silicon nanowires (SiNWs) were fabricated as supporting matrices for C-reactive protein (CRP) immobilization to construct CRP quantification biosensor. Anti CRP was immobilized onto SiNWs after chemical treatments such as aldehyde or carboxyl functionalized at the surface of SiNWs. Patients´ sera were systematically collected to monitor the changes of currents according to CRP concentration. For the detection of CRP, SiNWs showed a linear response and their corresponding signal changes were reported and CRP levels were measured beforehand by clinical diagnosis tools used in hospital for clinical examination.