Title :
Total arterial compliance is a major determinant of peak oxygen uptake
Author :
De Backer, TLM ; Carlier, SG ; Segers, P. ; Armstrong, G. ; Haluska, B. ; Greenberg, N. ; Marwick, T.H. ; Thomas, JD
Author_Institution :
Erasmus Med. Centre, Rotterdam, Netherlands
Abstract :
Total arterial compliance (TAC), defined as dV/dP, is a major component of the arterial system. A decreased TAC increases left ventricular load and has a detrimental effect on coronary perfusion. We sought to assess the influence of TAC on the functional reserve (VO2max). 14 patients (mean age 64±14y) with known or suspected coronary artery disease and 11 controls (34±5y) underwent supine bicycle exercise echocardiography. The audio Doppler signal output of the echocardiographic machine was digitized with a customized hardware and software interface simultaneously with carotid tonometry and ECG. TAC at rest was calculated by the pulse-pressure method (PPM). By step-wise forward multivariate analysis, independent predictors of VO2max were: patient vs. control status, peak exercise cardiac output and TAC. The described PC-based acquisition system for tonometry and Doppler signals permits the assessment of ventricular function and arterial biomechanics
Keywords :
Doppler measurement; blood flow measurement; blood vessels; cardiovascular system; data acquisition; echocardiography; electrocardiography; haemorheology; medical signal processing; microcomputer applications; oxygen; ECG; PC-based acquisition system; arterial biomechanics; arterial system; audio Doppler signal output; cardiovascular flow; carotid tonometry; coronary artery disease; coronary perfusion; customized interface; functional reserve; left ventricular load; patient status; peak O2 uptake; peak exercise cardiac output; pulse pressure method; signal digitization; step-wise forward multivariate analysis; supine bicycle exercise echocardiography; total arterial compliance; ventricular function assessment; Bicycles; Cardiac disease; Coronary arteriosclerosis; Echocardiography; Heart; Hypertension; Oxygen; Senior citizens; Stress; Testing;
Conference_Titel :
Computers in Cardiology 2001
Conference_Location :
Rotterdam
Print_ISBN :
0-7803-7266-2
DOI :
10.1109/CIC.2001.977621