A multimode plastic optical fiber platform coupled with aptamer layer for cancer biomarkers detection

Protein biomarkers are increasingly becoming significant analytical tools in the clinical practice. The introduction of new compact systems for sensitive, fast and simplified analysis is currently playing a substantial role in the development of point-of-care solutions driven by diagnostic and prognostic aims. The developed system represents a compact and miniaturized Lab-On-A-Chip (LOC) microdevice addressing the requirement of a rapid, portable, compact and low cost diagnostic platforms. For low-cost sensing systems, POFs are indeed especially advantageous due to their excellent flexibility, easy manipulation, great numerical aperture, large diameter, and thanks to the fact that plastic is able to withstand smaller bend radii than glass.